The ETS-1 transcription factor and proto-oncogene controlled by kinases regulate the expression of metalloproteinases, such as collagenase-1 (MMP-1), stromelysin (MMP-3), and urokinase-type plasminogen activator (uPA); thus, ETS-1 overexpression would favor a tumor progression associated with metalloproteinases MMP-1 [20]. The gene discussed is PLAU; the disease is neoplasm.