CSF1R and neoplasm: Figure 3B shows the progression of tumor burden by BLI analysis of two representative mice at two different time points (17 and 31 days after cell injection). The positive effect of CSF-1R expression on tumor growth was confirmed in a second experiment using N18 and N18-Fms cells (Figure 3C). Measurements of xenograft tumors collected with manual calipers showed that N18 control cells produced small tumors after a long lag phase (Figure 3C,D). In contrast, the rapid development of tumors was observed after N18-Fms injection (Figure 3C,D).