We selected three representative types of INH-ODN sequences in this study—namely, IRS 661, which specifically bound to TLR7; IRS 869, which was an inhibitory sequence of TLR9; and IRS 954, which was considered a dual antagonist to both TLR7/9—to investigate their immunosuppressive effects in lupus-model mice. This evidence concerns the gene TLR9 and systemic lupus erythematosus.