On the other hand, the top downregulated genes formed 4 subgroups and were related to melanogenesis (Wnt5a, Mitf, Pomc, Mc1r, Kit), melanoma (Fgf9, Fgf12, Fgf2), MAPK signaling pathway (Ncam1, Prkcb, Map3k4, Pla2g4a, Mapk14, Mapk11), and aging (Tgfbr1, Il6, Nox4). The gene discussed is POMC; the disease is melanoma.