Some of these proteins, such as Chymotrypsin-C, Alpha-amylase 1C, Alpha-amylase 2B, Calcium-activated chloride channel regulator 1 and Chymotrypsinogen B2, were mapped to the KEGG pancreatic secretion pathway and also reported as down-regulated in T1D in metaproteomics studies, more focused on the GM-host proteome relationship [28,29,30]. Here, CLCA1 is linked to type 1 diabetes mellitus.