GLP1R and type 2 diabetes mellitus: Quantitation showed that GLP-1R expression was increased in T2DM patients: the relative GLP-1R mRNA expression in the hypothalamus of diabetic individuals represented as 10,000*mRNA level/mRNA level of housekeeping genes (HKG) was 2.89 ± 0.9 in diabetics (among them, 1.39 ± 0.83 in Metformin-treated patients) and 0.52 ± 0.13 in control individuals (p < 0.05).