The presented findings that GLP-1 receptor is abundant in the magnocellular subdivision of the PVN (PVNmc) and is overexpressed in type 2 diabetes mellitus (T2DM) suggest that GLP-1R in the PVNmc may have special role in the dysregulation of feeding behaviour and glucose homeostasis in T2DM. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.