We performed a post mortem gene expressional study of the hypothalamus in patients of type 2 Diabetes Mellitus, using RT-qPCR, Western blotting, in situ hybridization histochemistry and immunohistochemistry and observed the presence of GLP-1 as well as GLP-1 receptor (GLP-1R) in the paraventricular hypothalamic nucleus (PVN). The gene discussed is GCG; the disease is diabetes mellitus.