Several SH2-containing proteins are involved in the development of certain types of cancers, such as breast cancer (Grb2, Grb7, STAT3, and Src), liver cancer (STAT3), Prostate cancer (STAT3, STAP2), Chronic Myelogenous Leukemia, CML (Bcl/Abl). This evidence concerns the gene GRB2 and chronic myelogenous leukemia, BCR-ABL1 positive.