Several SH2-containing proteins are involved in the development of certain types of cancers, such as breast cancer (Grb2, Grb7, STAT3, and Src), liver cancer (STAT3), Prostate cancer (STAT3, STAP2), Chronic Myelogenous Leukemia, CML (Bcl/Abl). Here, STAP2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.