Several SH2-containing proteins are involved in the development of certain types of cancers, such as breast cancer (Grb2, Grb7, STAT3, and Src), liver cancer (STAT3), Prostate cancer (STAT3, STAP2), Chronic Myelogenous Leukemia, CML (Bcl/Abl). The gene discussed is STAT3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.