Double-labeling immunofluorescence and confocal microscopy of p38-P Thr180/Tyr182 and AT8, and SAPK/JNK-P Thr183/Thr185 and AT8, in hTau mice inoculated with AD and GGT homogenates showed the co-localization of active tau kinases and phospho-tau deposition in neurons (Figure 5). This evidence concerns the gene MAPT and Alzheimer disease.