MAPT and argyrophilic grain disease: This applies to the present results for hTau mice and those we previously observed in WT mice: 3Rtau and 4Rtau inclusions are also produced following intracerebral inoculation of AD, GGT, ARTAG, and PiD sarkosyl-insoluble fractions in WT adult mice; inoculation of sarkosyl-insoluble fractions from PSP, FTLD-tau, and argyrophilic grain disease (AGD) also show 3Rtau- and 4Rtau-immunoreactive deposits in the host [57,58,60,61,62,91].