The current setting analyzes the profiles of tau seeding in hTau mice following the intra-hippocampal inoculation of sarkosyl-insoluble fractions from AD (3R + 4R tauopathy); Pick’s disease (PiD), a prototype 3R tauopathy; and globular glial tauopathy (GGT), a 4R tauopathy with characteristic globular and glial tau inclusions. The gene discussed is MAPT; the disease is Alzheimer disease.