DLG4 and Alzheimer disease: A recent study by Ortiz-Sanz et al. [59] showed that NMDAR NR2B and PSD-95 subunit levels were abnormally elevated in the postsynaptic terminals of the human prefrontal cortex in the early stages of AD, as well as in the hippocampus of 3xTg-AD mice, which was correlated with Aβ42 loading.