A reduction in MnSOD expression was found in the kidneys of unilateral ureteric obstruction (UUO)-induced renal fibrosis mice [115,116], while Parkinson disease protein 7 (PARK7) protected against chronic kidney injury and fibrosis by stimulating MnSOD expression, thus reducing oxidative stress in both tubular cells and kidney tissues of UUO mice [117]. The gene discussed is SOD2; the disease is renal fibrosis.