NFKB1 and Miyoshi myopathy: The target of the proteasome by PIs (bortezomib, carfilzomib, and ixazomib) interferes with some downstream pathways involved in MM survival (e.g., NF-κB, p53, and cyclins) and it also causes the accumulation of unfolded and misfolded proteins, triggering the apoptosis of PCs [101].