Conversely, they are the major producer of a proliferation, inducing ligand (APRIL) and B-cell-activating factor (BAFF), which promotes MM survival through the interaction with B-cell maturation antigen (BCMA) and other receptors [21,22] and with immune inhibitor molecules of immune cells, particularly indoleamine-2,3-dioxygenase (IDO) and programmed cell death ligand-1 (PD-L1) [23]. Here, CD274 is linked to Miyoshi myopathy.