However, the role of SIRT1 in BAT is highly debated, and some authors reported the UCP1 increase in BAT during ketosis [72], or in conjunction with the activation of the β3-adrenergic receptors [73]; whereas, others identified SIRT1 as the main protection from insulin resistance, and impaired β-adrenergic responses triggered by BAT inflammation. This evidence concerns the gene SIRT1 and Insulin resistance.