As for KBs, the role of SIRT1 in the regulation of metabolic homeostasis is carried out through the epigenetic control of food intake, the regulation of the glyco-lipidic profile, and the differentiation of adipocytes and the mobilization of fat, thus protecting against diseases such as atherosclerosis [21], hepatic steatosis [22,23], diabetes mellitus [24,25], and osteoporosis [26,27]. The gene discussed is SIRT1; the disease is fatty liver disease.