Considering that changes found are most likely consequential to the high levels of oxidative stress typical of motor neurons affected by ALS, in this work we wanted to extend our analysis also to the VDAC3 isoform purified from ALS-related NSC34-SOD1G93A cells and, as a control, from NSC34-SOD1WT or NSC34 cells. This evidence concerns the gene VDAC3 and amyotrophic lateral sclerosis.