The authors correlated specific polymorphisms in APOE4, TOMM40′650 and APOC1′623 with biothiol measurements (homocysteine and glutathione levels) in the plasma of AD patients and controls, providing an explanation for the development of AD in young age patients with inordinate oxidative stress responses due to TOMM40 and APOC1 rare variants [125]. This evidence concerns the gene APOC1 and Alzheimer disease.