VDAC2 and Alzheimer disease: Concerning the interaction between VDAC and cytoskeletal proteins, presuming that S-nitrosylation is a priming factor in protein folding [85], the observed nitrosylation of tubulins (TUBA-1A, 1B chain and TUBB-2C) and their interaction with ACT and hypernitrosylated VDAC2 might be a crucial factor that hampers microtubule architecture in AD and other neurodegenerative diseases.