In the 4TO7-Lin28B breast cancer model, tumor cells induce the production of IL6 and IL10 and trigger the neutrophil polarization toward a pro-tumor phenotype, in which the expression levels of arginase 1, CD206, Ym1, IL-4, IL-10, TGF-β, and IL-6 were increased while the expression levels of TNF-α, iNOS, IL-12a, and IL-1β were decreased [145]. Here, NOS2 is linked to neoplasm.