The experiment showed that AQP1, CYBA, MELK, PKD2, PRDX2 were significantly overexpressed in endometrial cancer, while ATP2B4, FOXO1, KCNMA1, KLF2, PRNP, SNCA, SOD3, THBS1, and TXNIP were downregulated. The gene discussed is KLF2; the disease is endometrial cancer.