Although it was related to the production of citrullinated autoantibodies, the inflammation and damage of lung mucosa and the development of a more severe RA disease [73], it seems that it is not only associated with the presence of ACPA, but rather with the concurrent presence of several autoantibodies in RA, since citrullination is not the only PTM that can be enhanced by tobacco. The gene discussed is PRTN3; the disease is rheumatoid arthritis.