HMGCR and obesity due to melanocortin 4 receptor deficiency: This piece can be added to further effects on different dysfunctions related to metabolism, such as insulin sensitivity [46], artery hypertension [47], and, in general, in metabolic disorders such as obesity and diabetes [48].The hypocholesterolemic effects induced by the flavanone are strictly related to its capability in modulating the protein network of cholesterol homeostasis acting on HMGCR activity and, intriguingly, reducing PCSK9 levels, a pharmacological target to treat hypercholesterolemia that is attracting the efforts of many researchers working in the field.