Ingenuity Pathway Analysis (IPA) revealed that pathways related to cytokine release (i.e., the role of hypercytokinemia/chemokinemia in the pathogenesis of influenza), inflammation (i.e., neuroinflammation signaling pathway) and Toll-like receptors (TLR) signaling (i.e., the role of PPRs in recognition of bacteria and viruses, activation of interferon regulatory factor–IRF-by cytosolic Pattern Recognition receptors, Toll-like receptor signaling) were all over-represented in Group 1 BMDMs (Figure 3A,B). Here, TRIM63 is linked to influenza.