Further additional experiments show that the development of Ang II-induced hypertension via systemic Ang II infusion was also significantly attenuated by half in adult male PT-Nhe3−/− mice (WT + Ang II: 157 ± 5 mmHg vs. PT-Nhe3−/− + Ang II: 129 ± 3 mmHg; p < 0.01) (Figure 5C), suggesting a similar contribution of systemic vs. proximal tubule Ang II/AT1a receptor systems in the development of Ang II-induced hypertension [32,33,34,35,41,42]. The gene discussed is SLC9A3; the disease is hypertensive disorder.