However, we and others have previously shown that AT1 (AT1a) receptors are widely expressed and localized in virtually all Ang II-targeting tissues or cells, ranging from the brain, heart, blood vessels, kidney, and adrenal glands that contribute to maintenance of basal blood pressure homeostasis and the development of hypertension [43,44,46,47,48,49]. This evidence concerns the gene AGT and hypertensive disorder.