REN and hypertensive disorder: The lack of blood pressure responses was demonstrated despite that intratubular renin mRNA expression in the cortex increased significantly in both clipped (Control: 10,195 ± 1352 copies/ng RNA vs. 2K1C: 17,378 ± 3103 copies/ng RNA, p < 0.01) and nonclipped kidneys (2K1C: 19,620 ± 2844 copies/ng RNA, p < 0.01 vs. control) in Agtr1a−/− mice during the development of 2K1C hypertension (Figure 3B).