AGT and secondary hypertension: A critical role for Ang II via activating AT1 (AT1a) receptors to induce 2K1C Goldblatt hypertension has been reported previously in rats [10,11,12,13,14], mice [15,16,26,27,28], and humans with secondary hypertension due to renal arterial stenosis that significantly decreases renal blood flow to the kidney [3,8,9].