The data from the present study unequivocally showed that compared with WT as well as whole-body Agtr1a−/− mice, induction of 2K1C hypertension by clipping the left renal artery did not significantly increase the expression of renin, angiotensinogen, and ACE mRNAs in the clipped kidney of PT-Agtr1a−/− mice. The gene discussed is REN; the disease is hypertensive disorder.