Recently, we have shown that deletion of AT1a receptors or NHE3 selectively in the proximal tubules significantly attenuated Ang II-induced hypertension with systemic Ang II infusion, which strongly suggests that the development of 2K1C hypertension may also be attenuated in PT-Agtr1a−/− or PT-Nhe3−/− mice [32,33,34,35]. This evidence concerns the gene AGT and hypertensive disorder.