The failure of the development of 2K1C hypertension in PT-Agtr1a−/− mice was associated with the lack of significant increases in the expression of renin mRNAs (Control: 2402 ± 134 copies/ng RNA vs. 2K1C: 2517 ± 305 copies/ng RNA, n.s.)(Figure 4B), angiotensinogen mRNAs (Control: 616 ± 47 copies/ng RNA vs. 2K1C: 474 ± 134 copies/ng RNA, n.s.)(Figure 4C), ACE mRNAs (Control: 1740 ± 103 copies/ng RNA vs. 2K1C: 1495 ± 96 copies/ng RNA, n.s.)(Figure 4D), and plasma Ang II (Control: 28.4 ± 4.5 fmol/mL vs. 2K1C: 37.4 ± 6.5 fmol/mL, n.s.)(Figure 4E). The gene discussed is REN; the disease is hypertensive disorder.