Subsequent studies by Cervenka et al. and others have further shown that whole-body deletion of AT1a receptors blocked the development of 2K1C hypertension in Agtr1a−/− mice, supporting a key role of systemic AT1a receptors in the development of 2K1C hypertension [15,16,26,27,28]. This evidence concerns the gene AGTR1 and Hypertension.