Further bioinformatic analysis revealed that downregulated miRNA sequences may be engaged in several biological processes, which might regulate programed cell death through positive regulation of apoptotic process (miR-16), positive regulation of intrinsic apoptotic signaling pathway (miR-16), positive regulation of necroptotic process (miR-107), and cellular response to hydrogen peroxide (miR-107) in CD34+ hematopoietic stem and progenitor cells from CS patients. Here, CD34 is linked to Cowden syndrome 1.