TM6SF2 and steatosis: Moreover, Tm6sf2 liver-specific knockout mice exhibited increased steatosis and fibrosis after the consumption of a high milk-fat diet (60.3% kcal from fat, primary milk fat) for three weeks, with those phenotypes being further exacerbated when mice were fed fibrogenic, high fat/fructose diets for 20 weeks [either a trans-fat, fructose supplemented diet with 45.3% kcal from fat, containing 22% hydrogenated vegetable oil and consuming sugar water containing 55% fructose/45% glucose (4.2g/L) or a palm oil diet (40% kcal fat) supplemented with 20% kcal fructose and 2% cholesterol] [109].