APOE and metabolic dysfunction-associated steatohepatitis: However, when ApoE−/− mice consume a Western-type, cholesterol-enriched diet [42% energy as fat (with coconut oil), 1.25% cholesterol] for seven weeks, they show abnormal glucose tolerance, increased levels of fasting glucose, hepatomegaly, weight gain and develop the full spectrum of NASH spanning from hepatic steatosis and hepatocyte ballooning to inflammation and fibrosis [76].