Hyperlipidemic ldlr−/− mice are one of the two best characterized dyslipidemic models [69] and were first used as a model for atherosclerosis research, but when they were fed a high-fat diet with cholesterol (HFC) (21% milk butter, 0.2% cholesterol) for seven days the female mice developed steatosis with severe inflammation characterized by infiltration of macrophages and increased NF-κB signaling, while the male ones developed severe hepatic inflammation in the absence of steatosis [68]. The gene discussed is NFKB1; the disease is steatosis.