Overall, the genetic alterations that have been introduced/utilized in mice models for NAFLD are rarely found in humans, or those that predispose to NAFLD in humans and are used to create mouse models (e.g., the PNPLA3I148M and Tm6sf2 hepatic knockdown or knockout mice) do not seem to induce the same effects in the animal models. This evidence concerns the gene TM6SF2 and metabolic dysfunction-associated steatotic liver disease.