Hepatocyte-specific null mutation of Pten in mice has led to PTEN-deficient mice that display massive hepatomegaly and steatohepatitis with an accumulation of triglycerides, inflammatory cells and Mallory-Denk bodies, followed by liver fibrosis and HCC, closely mimicking the NASH phenotype/progression in humans [117,118]. This evidence concerns the gene PTEN and hepatocellular carcinoma.