PTEN and hepatocellular carcinoma: Notably, liver tumors appear in 66% of the male and 30% of the female PTEN-deficient mice at 40–44 weeks of age and in 100% of PTEN-deficient mice at 74–78 weeks, with 66% of the tumors at 74-78 weeks being HCC (83% in male and 50% in female mice of that genotype) [117].