When ALR-H-KO mice were administered a high-fat/high-carbohydrate (HF/HC) diet (60% kcal fat plus 2.3% fructose and 1.9% sucrose in drinking water) and were compared to WT and hepatocyte-specific ALR-heterozygous (ALR-H-HET) mice consuming the same diet, it was shown that the ALR-H-KO mice gained the least weight and had the least steatosis, whilst also had lower insulin resistance (all these HF/HC-fed mice developed insulin resistance) [120]. This evidence concerns the gene IL13 and Insulin resistance.