More specifically, when WT C57BL/6 mice are fed an HFD for 10–12 weeks, they develop steatosis, as shown by increased lipid accumulation, hyperlipidemia, hypercholesterolemia, hyperinsulinemia and glucose intolerance [10,15], whilst when the HFD is administered for 16 weeks then hepatocyte fat accumulation, ballooning, and Mallory-Denk bodies are observed, as well as decreased serum levels of the anti-inflammatory adipokine adiponectin and higher fasting serum glucose levels [6,17]. This evidence concerns the gene ADIPOQ and hyperinsulinism.