In order to mimic PNPLA3-induced fatty liver disease, transgenic mice in a C57BL/6 background were generated that express human PNPLA3 wild-type (PNPLA3WT) or the 148M variant (PNPLA3I148M) in the liver and adipose tissue [31], or the codon 148 of Pnpla3 in the mouse genome was changed from ATT to ATG, substituting methionine for isoleucine (PNPLA3I148M) [32]. The gene discussed is PNPLA3; the disease is fatty liver disease.