The E167K variant of the Tm6sf2 gene is strongly associated with hepatic triglyceride content and favors hepatic fat accumulation in intracellular lipid droplets since it decreases lipid secretion, leading to increased susceptibility to liver damage, including NASH and severe fibrosis, whilst it also predisposes humans to NAFLD with progression to HCC [30,108]. This evidence concerns the gene TM6SF2 and metabolic dysfunction-associated steatotic liver disease.