High branching has been associated with glycosylation changes in some major APPs; transferrin glycans showed increased branching in rheumatoid arthritis [59] and ulcerative colitis [60], HPT glycans exhibited higher branching in pancreatic, hepatic, ovarian, and prostate cancer [61], A1AT glycans in hepatocellular carcinoma [62], while AACT showed higher branching in septic patients [63]. This evidence concerns the gene TF and rheumatoid arthritis.