Both C-X-C motif ligand 1 (CXCL-1) and C-X-C motif ligand 2 (CXCL-2) are chemokines that influence prostate cancer cells, and curcumin therapy greatly lowers the transcription of both chemokines [277] by blocking NF-κB activation by preventing the phosphorylation of NF-κB inhibitor and downstream phosphorylation of P65. This evidence concerns the gene NFKB1 and Familial prostate cancer.