Wang et al. uncovered that lncRNA H19 affects the binding of DNMT3B and the Beclin1 promoter region by altering the SAH accumulation subsequently downregulating the methylation of the Beclin1 promoter and promoting tamoxifen resistance and autophagy via the H19/SAHH/DNMT3B axis in BC cells [84]. This evidence concerns the gene DNMT3B and breast cancer.