It has been reported that other components of para-speckle bodies, non-POU domain-containing octamer-binding protein (NONO) and paraspeckle component 1 (PSPC1), are intactly localized within para-speckle bodies in ALS-TDP [138], in contrast to SFPQ, FUS, and TDP-43. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.