The motor neuron TDP-43 pathology in PSP and CBD patients also showed a difference from that in ALS/FTLD-TDP; the TDP-43 pathology was consistently prominent in the cervical cord, which forms a great contrast with ALS/FTLD-TDP, which involves broad segments and brainstem motor neurons. This evidence concerns the gene TARDBP and supranuclear palsy, progressive, 1.