Postmortem studies have reported that TDP-43 aggregates can be observed in brain tissue under non-ALS/FTLD disorders, including AD [64,65] (Figure 3), PSP [66,67] (Figure 3), CBD [68,69] (Figure 3), Lewy body diseases [70,71,72], hippocampal sclerosis [73], post-traumatic chronic encephalopathy [74], and brain tumors [75]. Here, TARDBP is linked to Alzheimer disease.