OPTN and inclusion body myositis: Optineurin (OPTN), progranulin, C9orf72, CHMP2B, transmembrane protein 106B (TMEM106B), VCP, and mTOR-signaling pathway are key molecules participating in the autophagosome-lysosome system [117], and the immunohistochemical properties of inclusion bodies observed in IBM muscles are highly similar to those of GVD [100].