Transactivation response DNA binding protein 43 kDa (TDP-43/TARDBP) is a pathological protein observed in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) [1,2,3], and a subset of aged people also show TDP-43-related pathology [4]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.