TDP-43 pathology in the AD brain is morphologically similar to LATE and also spreads in a LATE-like hierarchy; it starts from the amygdala (stage 1) and then moves to the entorhinal cortex and subiculum (stage 2); to the dentate gyrus of the hippocampus and occipitotemporal cortex (stage 3); to the insular cortex, ventral striatum, basal forebrain, and inferior temporal cortex (stage 4); to the substantia nigra, inferior olive, and midbrain tectum (stage 5); and finally to the basal ganglia and middle frontal cortex (stage 6) [10]. The gene discussed is TARDBP; the disease is Alzheimer disease.