HIF1A and neoplasm: Our previous study demonstrated that melittin-dKLA effectively suppressed TNBC lung metastasis through the elimination of M2-like TAMs, accompanied by a reduction in the expression of tumor-development-related genes, such as CD44, CC motif chemokine ligand (CCL)22, hypoxia-inducible factor (HIF)-1α, and MMP9 [50].