In another study, apigenin (150 mg/kg/day administered via oral gavage) significantly reduced tumor size, increased the abundance of CD4+ and CD8+ cytotoxic cells, and decreased the expression of immunosuppressive protein PD-L1 on DC isolated from mice xenografted with melanoma B16-F10 cells [207], suggesting that apigenin treatment improved the functional activity of DCs. The gene discussed is CD4; the disease is neoplasm.