In both recurrence and non-recurrence groups from patients with HNSCC who had previously received definitive surgery and adjuvant radiotherapy, high phosphorylation levels of PI3K, AKT, mTOR, eukaryotic initiation factor 4E (eIF4E), and eIF4E binding protein 1 (4EBP1) were observed [24,25]. This evidence concerns the gene EIF4E and head and neck squamous cell carcinoma.