Regular exercises have been shown to increase the release of anti-inflammatory cytokines and they lead to a reduction in pro-inflammatory cytokines, e.g., TNF-α and interleukin 1β (IL-1β), interleukin 6 (IL-6), interleukin 18 (IL-18), CRP, which play a role in the pathogenesis of diabetes [16]. The gene discussed is IL18; the disease is diabetes mellitus.