The activation and overexpression of CIP2A in tumor cells have been investigated by several studies in which CIP2A was found to be associated with several molecules of the signaling pathways that regulate tumor proliferation and apoptosis, including C-Myc, DAPK1 (death-associated protein kinase 1), E2F1 (oncogenic transcription factor) and Plk1 (polo-like kinase 1) [53,54]. Here, E2F1 is linked to neoplasm.