A clinical phenotype associated with EDA gene mutation is X-linked hypohidrotic ectodermal dysplasia (XLHED), also named as anhidrotic/hypohidrotic ectodermal dysplasia (HED), which is the most common genetic disorder of ectodermal development in humans resulting in hypotrychosis, hypodontia, heat intolerance, dry skin, susceptibility to airways infections and crusting of various secretions [36]. The gene discussed is EDA; the disease is autosomal dominant hypohidrotic ectodermal dysplasia.