An in vitro and in vivo study in pancreatic cancer models demonstrated that double inhibition by using nano micelles containing NVP-BEZ 235 (PI3K-γ inhibitor) and CSF-1R-siRNA (CSF-1R inhibitor) remodeled the TAMs and synergistically activated antitumor immune responses, providing an alternative approach in counteracting tumor progression [64]. The gene discussed is CSF1R; the disease is pancreatic neoplasm.