Obesity leads to the induction of aromatase expression in adipose stromal cells (ASCs) and enhances estrogen levels as a result of increased COX-2 expression and elevated levels of proinflammatory mediators and cytokines: TNFα, IL-1, and IL-6 [125,126]. This evidence concerns the gene CYP19A1 and obesity due to melanocortin 4 receptor deficiency.