Selected signaling pathways, MAPK, nuclear factor kappa B (NF-kB), Janus kinase/signal transducers and activators of transcription (JAK-STAT), toll-like receptor (TLR) pathways, cGAS/STING, and MAP kinase connected with chronic inflammation are supposed to be responsible for the development of cancers. This evidence concerns the gene NFKB1 and cancer.