HAS2 and osteosarcoma: It was shown that incubation of cells for 24 h in the presence of 1 μM DXM induces rapid (1–2 h) and sustained, near-total (97 ± 98%) suppression of human hyaluronan synthase 2 (HAS2) (responsible for HA biosynthesis) in cultured human dermal fibroblasts and the MG-63 osteoblast-like osteosarcoma cell line through substantial decreases in both gene transcription and message stability [53].