Immunohistochemical analysis also revealed that the cortical tubulointerstitium expression of fibronectin was higher in control 18-month-old rats than control 3-month-old rats, as well as WD 18-month-old male rats than WD 3-month-old male rats (Age: F1,43 = 72.77, p < 0.0001, Figure 3). The gene discussed is FN1; the disease is Wilson disease.