Indeed, previous reports have shown that the HDACi vorinostat (suberoylanilide hydroxamic acid) downregulates the expression of the DSB repair proteins RAD50 and MRE11A in prostate and lung cancer cells [38], as well as the expression of the NHEJ proteins Ku70 and Ku80, and the homologous recombination factor RAD50 in melanoma cells [39]. This evidence concerns the gene XRCC5 and melanoma.