TARDBP and Alzheimer disease: All of the plasma samples from the control and AD cases were analyzed for reactivity with a panel of 9 scFvs; three that bind different Aβ variants (A4, C6T, and E1), five that bind different tau variants (D11C, F9T, ADTau2, ADTau4, and ADTau6) and one that binds a TDP-43 variant (AD-TDP3) (Table 1).