MAPT and Alzheimer disease: To demonstrate the potential of a multiparameter personalized diagnostic assay for AD, we utilized a panel of nine previously generated and characterized single-chain variable fragments (scFvs) that selectively bind AD-related variants of Aβ, tau, and TDP-43 [19,20,21,22,23,24,25,26,27,28,29,30,31,32] (Table 1).