AKT1 and cardiovascular disorder: In our study, by inputting hsa-miR-200c-3p, IL-7, VCAM-1 and VEGF-C into the IPA analysis together with glucose to simulate the diabetic state, we predicted that downregulated miR-200c may lead to cardiovascular disease through VEGF signaling and PI3K/Akt signaling pathways (Figure 5).