Since hyperglycemia augments miR-200c expression in target cells (EC), but not in the immune regulatory cells such as PBMCs, a possible explanation is that miR-200c expression may be downregulated indirectly by factors such as proinflammatory cytokines; as detected by previous studies, IL-6 is negatively correlated with miR-200c-3p expression in inflammatory diseases [44,45] and also IL-8 [46]. The gene discussed is CXCL8; the disease is Hyperglycemia.