TNF-α (p = 0.0009) and uPAR (p < 0.0001) were downregulated by PEDF compared to controls under pre-menopausal conditions only (Figure 1U–X,AC–AF,e,g); while, MT1-MMP (p < 0.0001) and RANKL (p < 0.0001) were downregulated in post-menopausal conditions only in MDA-MB-231 cells (Supplementary Figure S1E–H,M–P,a,c). Here, TNF is linked to atrial fibrillation.