Overall, we report for the first time that p-NFκB-p65, TNF-α, CXCR4, and uPAR are PEDF anti-metastatic targets specific to post-menopausal conditions in ER+/HER2- BC cells, with p-NFκB-p65 and uPAR also specific to pre-menopausal TNBC. Here, CXCR4 is linked to breast cancer.