To summarise, PEDF exhibited the greatest downregulatory effect on p-NFκB-p65, TNF-α, CXCR4, and uPAR expression under post-menopausal conditions in ER+/HER2- BC, and on p-NFκB-p65 and uPAR under pre-menopausal conditions in TNBC cells. This evidence concerns the gene NFKB1 and breast cancer.