Additionally, we found PEDF is downregulated under post-menopausal oestrogen conditions in ER+/HER2- BC and TNBC cells in vitro, and PEDF anti-metastatic function is enhanced under post-menopausal conditions for ER + BC cells and under pre-menopausal conditions for TNBC cells (manuscript submitted). The gene discussed is ERBB2; the disease is breast cancer.