Hodgkin lymphomas (HLs) are a heterogeneous group of lymphoid neoplasia that are derived from B-cells and histologically consist of large neoplastic cells (CD30+ Hodgkin and Reed–Sternberg cells, HRS) and a diverse group of reactive bystander cells (histiocytes, lymphocytes, plasma cells, epitheliod histiocytes, epithelioid granulomas and eosinophils, depending on the HL type [1]. This evidence concerns the gene TNFRSF8 and Hodgkins lymphoma.