PDLIM7 and nasopharyngeal carcinoma: The loss of a restriction site in the exon 1 of the LMP1 gene, e.g., XhoI polymorphism frequently observed in NPC patients of Asian origin, has been associated with an increased oncogenic potential both in vitro (leading to the transformation of Balb/c 3T3 cells) and in vivo (a tumorigenic effect in nude mice) [51].