PDLIM7 and nasopharyngeal carcinoma: Studies in LMP1-positive and -negative NPCs demonstrated increased immunogenicity of the B-cell-derived LMP1 isolate (wild-type B95-8) that exhibited a low mutagenic frequency in comparison with the highly mutated NPC CAO strain protein suggesting that LMP1-positive tumors escape immune surveillance by selecting for LMP1 mutations or similar mechanisms (the down-regulation of LMP1 expression, promotor methylation) allowing for immune evasion in immunocompetent hosts [52].