APN protects the cardiovascular system by protecting myocardial cells, improving endothelial cell function, reducing oxidative stress and inflammation, slowing cardiovascular system diseases with glucose and lipid metabolism disorders as the main triggers, including atherosclerosis, hypertension, myocardial hypertrophy, myocardial ischemia, and myocardial infarction. The gene discussed is ANPEP; the disease is cardiac hypertrophy.