APN protects the cardiovascular system by protecting myocardial cells, improving endothelial cell function, reducing oxidative stress and inflammation, slowing cardiovascular system diseases with glucose and lipid metabolism disorders as the main triggers, including atherosclerosis, hypertension, myocardial hypertrophy, myocardial ischemia, and myocardial infarction. This evidence concerns the gene ANPEP and myocardial ischemia.