For example, there is increasing acknowledgment of the multifactorial and synergistic nature of late pregnancy insulin resistance, with important roles for GH-V (a powerful lipolytic hormone), maternal insulin like growth factor 1 (IGF-1), progesterone, cortisol and tumor necrosis factor (TNFα); as well as a fall in adiponectin [9]. The gene discussed is GH2; the disease is Insulin resistance.