Microglia in mutant SETD2 (SETD2-mut)/IDH-WT GBM exhibit pro-inflammatory and proliferative phenotypes probably through stimulation of glioma-derived TGF-β1 expression via the apolipoprotein E (ApoE)-mediated NLRP1 inflammasome [77]. The gene discussed is SETD2; the disease is glioblastoma.