IDH2 and astrocytoma (excluding glioblastoma): Interestingly, pleomorphic xanthoastrocytoma (PXA) shows increased CXCL14 secretion and contains a higher number of activated cytotoxic CD8+ T cells, increased expression of MHC class I and other genes associated with antigen presentation and processing as well as a higher number of AIF1 (Iba1)+ immunoreactive microglia/macrophages when compared to IDH-mutant astrocytoma [109].