Glioma-induced conversion of microglia into glioma supportive cells is associated with an increase of H4K16 acetylation in microglia and augmented nuclear relocation of the deacetylase SIRT1, which in turn stimulates deacetylation of the H4K16 acetyltransferase hMOF and its recruitment to promoter regions of genes involved in microglia activation (Ccl22, Chil3, Il6, Mmp14) [151]. The gene discussed is SIRT1; the disease is glioma.