A subsequent study by the same authors [75] has shown that glioma-derived FGL2 induces secretion of PPBP (CXCL7) by a subset of TAMs following activation of FGL2/CD16/PI3K/Akt/HIF1α signalling, which promotes the expression of stem-like properties in glioma cells (Figure 3, Molecular event 23). Here, AKT1 is linked to central nervous system cancer.