Strikingly, the protein complex formed by CHI3L1-Gal3 promotes the infiltration of “pro-tumour” M2 but not “anti-tumour” M1 macrophages and appears to be regulated transcriptionally by NF-κB/CEBPβ in the CHI3L1/Gal3/PI3K/Akt/mTOR axis [33]. Here, CHI3L1 is linked to neoplasm.