The view is also supported by Hu et al. [99] who report that overexpression of the LRIG2 (Leucine Rich Repeats And Immunoglobulin Like Domains 2) gene in GBM cells induces upregulation of CD47 and activation of the CD47-SIRPα anti-phagocytic axis [30]. The gene discussed is CD47; the disease is glioblastoma.