Huang et al. have used an ex vivo model of induced pluripotent stem cell (iPSC)-derived human microglia/macrophages and shown that the cells upregulate CCL18 and induce glioma cell growth and invasion via the CCR8/ACP5/AKT1S1 (PRAS40)/Akt pathway [82] (Figure 3, Molecular event 30). This evidence concerns the gene AKT1S1 and central nervous system cancer.