SLC9A1 and central nervous system cancer: Another study has shown that Na+/H+ exchanger isoform 1 (NHE1), a major interaction partner of calmodulin, stimulates microglial release of soluble factors leading to enhanced glioma proliferation and invasion [114] whereas blockage of NHE1 improves glioma tumour immunity by restoring mitochondrial OXPHOS (oxidative phosphorylation) function in myeloid cells [115].