Mutant IDH1 (IDH1-mut) glioma cells downregulate ICAM1 via ICAM1 promoter methylation resulting in an increased expression of LAMP1 (CD107a), a lysosome-associated membrane protein which has a key role in the formation of phagolysosomes [125] (Figure 3, Molecular event 24). The gene discussed is ICAM1; the disease is central nervous system cancer.