We speculated that the differential expression may be involved in the respective tumor microenvironment and major fatty acid uptake patterns of the tumors, for example, leukemic cells can uptake fatty acids from the microenvironment directly using CD36 or the fatty acid binding protein FABP4 in LAML [34,35], and CD36+ LSC can obtain energy directly from the fatty acid oxidation process of adipocytes in the bone marrow microenvironment [36]; these may ultimately lead to a less dependence of LAML on FASN-mediated de novo fatty acid synthesis. This evidence concerns the gene FASN and neoplasm.