MSH2 and cancer: The main cause of MSI was the genetic variation or epigenetic alteration of DNA mismatch repair (MMR); therefore, we analyzed the main members of the MMR system, MutL homolog 1 (MLH1), MutS protein homolog 2 (MSH2), MutS Homolog 6 (MSH6), and PMS1 homolog 2 (PMS2) and found that they were associated with FASN expression, and the results revealed that the FASN and MMR genes were significantly positively correlated with 29 cancers (Figure 5C).