PTEN and thyroid gland papillary carcinoma: The miR-200c has been found to promote papillary thyroid cancer cell proliferation, migration, and invasion of papillary thyroid cancer cell by downregulating PTEN [43], while overexpression of PTEN decreased the proliferation and differentiation of mammary epithelium in mice, and increased cell apoptosis, resulting in the death or growth postponement of newborn offspring [44].