HMOX1 and asthma: In addition, ovalbumin-induced asthma decreased the expression of IFN-γ levels, while DADS treatment significantly increased the expression of IFN-γ and the expression of antioxidant proteins, such as nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and hemeoxygenase-1 (HO-1) in experiments in vivo and in vitro, leading to reduced ROS production [19].