GJA1 and amyotrophic lateral sclerosis: Almad et al. provided evidence of upregulated Cx43 GJs and Cx43 hemichannels in cellular membranes of iPSC-derived astrocytes (hiPSC-A) from familial and sporadic case of ALS, which stresses the importance of novel GJ-modifying therapies for AD, ALS, and inflammatory neurodegenerative disorders [58].