WNT11 and neoplasm: In addition, tumour progression is enhanced by CAFs IL-8 secretion [233], CAFs exosomes autocrine induction of Wnt-11 [234], potentiation of the neoplastic EMT process for tumour extravasation [149], or by CAFs MMPs secretion to trigger the COX2-NF-B cascade, as seen in prostate cancer cells and promotion of ROS accumulation and invasion [235] (Table 1).