It is essential for cell migration, EMT, ECM invasion, and in maintaining the stemness of tumour cells by either binding to integrins and CD44 or by activating the NF-Kb, MEK/MAPK, PI3K/Akt, and FAK pathways [44,79,105,106] (Figure 2 and Figure 3). The gene discussed is NFKB1; the disease is neoplasm.