As depicted by the green arrows in Figure 1, positive amplification feedback loops are active in severe COVID-19 where overly exuberant granulopoiesis leads to NLRP3 inflammasome assembly that in turn creates further neutrophilia with related tissue damage and MDSC related immune suppression, triggering further NLRP3 inflammasome assembly, etc. [53,54,55]. Here, NLRP3 is linked to COVID-19.